Acetone → [2-(4-Fluorophenyl)ethyl](propan-2-yl)amine

HRID 1351257ノート

反応式

HRID 1351257 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][CH:3]=1.[CH3:11][C:12]([CH3:14])=O.CO.C([BH3-])#N.[Na+]>C(O)(=O)C.C(OCC)(=O)C.O>[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH:8][CH:12]([CH3:14])[CH3:11])=[CH:4][CH:3]=1

参加物

8

反応物 4

HCID 180AcetoneHCID 887MethanolHCID 4653p-FluorophenethylamineHCID 5003444Sodium cyanoborohydride

生成物 1

HCID 21098562[2-(4-Fluorophenyl)ethyl](propan-2-yl)amine

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 4-fluorophenethylamine (1.4 g) in acetic acid (10 mL) was added dropwise acetone (0.82 mL) and methanol (20 mL). After sodium cyano-borohydride (0.64 g) was added, and the solution was stirred at room temperature for 2.5 hours. After adding water and diluting with ethyl acetate, the solution was washed with water and saturated sodium chloride water. After drying with anhydrous sodium sulfate, the residue that was obtained upon removing the solvent by evaporation was purified by NAM silica gel column chromatography (hexane/ethyl acetate), and the title compound (0.62 g) was obtained as colorless solids.

後処理

  1. washthe solution was washed with water and saturated sodium chloride water
  2. dry with materialAfter drying with anhydrous sodium sulfate
  3. customthe residue that was obtained
  4. customupon removing the solvent
  5. customby evaporation
  6. customwas purified by NAM silica gel column chromatography (hexane/ethyl acetate)

出典と根拠

ORDレコード
ord-7b3d68e78fb04411aa64ef3012cb2c39
出典データセット
uspto-grants-2007_05
特許番号
US07217723B2

反応ノート

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