ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Methyl iodide → 7-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(2,4-difluorophenyl)-2-hydroxy-ethyl]-methyl-amide

HRID 1351279
ノート
印刷プレビュー

反応式

HRID 1351279 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]([OH:25])[CH2:10][NH:11][S:12]([C:15]1[C:16]2[CH2:23][CH2:22][CH2:21][C:20](=[O:24])[C:17]=2[S:18][CH:19]=1)(=[O:14])=[O:13].[C:26](=O)([O-])[O-].[K+].[K+].CI.C(OCC)(=O)C>CN(C)C=O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]([OH:25])[CH2:10][N:11]([CH3:26])[S:12]([C:15]1[C:16]2[CH2:23][CH2:22][CH2:21][C:20](=[O:24])[C:17]=2[S:18][CH:19]=1)(=[O:14])=[O:13]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 210986777-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(2,4-difluorophenyl)-2-hydroxy-ethyl]-amide

生成物 1

HCID 210986787-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(2,4-difluorophenyl)-2-hydroxy-ethyl]-methyl-amide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid[2-(2,4-difluorophenyl)-2-hydroxy-ethyl]-amide (the compound of Preparation Example 51) (197 mg) in N,N-dimethylformamide (3 mL) was added potassium carbonate (140 mg) and methyl iodide (0.1 mL). After stirring at room temperature for 1 hour, ethyl acetate was added, and the precipitate was removed by filtration. The solvent was evaporated at reduced pressure. Purification was carried out by silica gel column chromatography (hexane/ethyl acetate), and the title compound (190 mg) was obtained as a colorless candy-like substance.

後処理

  1. customthe precipitate was removed by filtration
  2. customThe solvent was evaporated at reduced pressure
  3. customPurification

出典と根拠

ORDレコード
ord-03d59c623a5d46f092cf9112eb25dd94
出典データセット
uspto-grants-2007_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07217723B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート