5-Bromothiophene-2-sulfonyl chloride → 5-BroMo-thiophene-2-sulfonic acid M ethylaMide
反応式
[Br:1][C:2]1[S:6][C:5]([S:7](Cl)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[CH3:11][NH2:12].O1CCCC1>O1CCCC1.O>[CH3:11][NH:12][S:7]([C:5]1[S:6][C:2]([Br:1])=[CH:3][CH:4]=1)(=[O:9])=[O:8]参加物
5
実験手順
To a solution of 5-bromothiophene-2-sulfonyl chloride (602 mg) in tetrahydrofuran (5 mL) was added dropwise a solution of 2.0M methylamine-tetrahydrofuran (3.5 mL) on an ice bath. After stirring for 15 minutes on an ice bath, the solution was diluted with water and extracted with ethyl acetate. After washing with an aqueous solution of saturated sodium bicarbonate and saturated sodium chloride water, the solution was dried with anhydrous sodium sulfate. After filtration through silica gel, the solvent was removed by evaporation to provide the title compound (608 mg) as a colorless oily matter.
後処理
- extractionextracted with ethyl acetate
- washAfter washing with an aqueous solution of saturated sodium bicarbonate and saturated sodium chloride water
- dry with materialthe solution was dried with anhydrous sodium sulfate
- filtrationAfter filtration through silica gel
- customthe solvent was removed by evaporation
出典と根拠
- ORDレコード
- ord-4099beedcf60446f997ddb36507e5321
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07217723B2
反応ノート
読み込み中…