Benzyl Alcohol → Benzyl 5-amino-4-oxopentanoate--hydrogen chloride (1/1)

反応式

[ClH:1].[NH2:2][CH2:3][C:4](=[O:10])[CH2:5][CH2:6][C:7]([OH:9])=[O:8].[CH2:11](O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[ClH:1].[NH2:2][CH2:3][C:4](=[O:10])[CH2:5][CH2:6][C:7]([O:9][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:8]

参加物

反応物 2

HCID 244Benzyl Alcohol

HCID 123608Aminolevulinic Acid Hydrochloride

生成物 1

HCID 22253144Benzyl 5-amino-4-oxopentanoate--hydrogen chloride (1/1)

実験手順

From benzyl alcohol (50 ml) and 5-amino-4-oxopentanoic acid hydrochloride (10.0 g; 60 mmol). After 23 h at 90°, excess benzyl alcohol was distilled off at 90° (bath temperature) and 0.33 mm Hg. The yield was 8.1 g (53%) of tan powder.

後処理

distillationexcess benzyl alcohol was distilled off at 90° (bath temperature) and 0.33 mm Hg

出典と根拠

ORDレコード: ord-0610bba37bcb4d80bd8122fa5c6d483c
出典データセット: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07217736B2

反応ノート

読み込み中…