Trifluoroacetic acid → 4-[(3-Methoxy-pyrazin-2-ylamino)-methyl]-piperidine

HRID 1351580ノート

反応式

HRID 1351580 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]2[C:21]([O:22][CH3:23])=[N:20][CH:19]=[CH:18][N:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[CH3:23][O:22][C:21]1[C:16]([NH:15][CH2:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:17][CH:18]=[CH:19][N:20]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 235773124-[(3-Methoxy-pyrazin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 221357494-[(3-Methoxy-pyrazin-2-ylamino)-methyl]-piperidine

実験手順

4-[(3-Methoxy-pyrazin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (0.5 g, 0.0015 mol) and trifluoroacetic acid (5 mL) were allowed to stir under nitrogen for 0.5 h. The reaction was concentrated in vacuo, and chromatographed on silica using methylene chloride/methanol/ammonium hydroxide (90/10/2) to give the title compound. M.S. (M+1): 223.

後処理

  1. concentrationThe reaction was concentrated in vacuo
  2. customchromatographed on silica

出典と根拠

ORDレコード
ord-fe5342dcd0844061a8b4fc1d1bcc0bc6
出典データセット
uspto-grants-2007_05
特許番号
US07217716B2

反応ノート

読み込み中…