Triethylamine → 2-Fluoro-3-(4-methyl-piperazin-1-yl)-6-nitro-phenylamine
反応式
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.CN1C(=O)CCC1.C(N(CC)CC)C.F[C:23]1[CH:24]=[CH:25][C:26]([N+:31]([O-:33])=[O:32])=[C:27]([C:29]=1[F:30])[NH2:28]>O>[F:30][C:29]1[C:23]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)=[CH:24][CH:25]=[C:26]([N+:31]([O-:33])=[O:32])[C:27]=1[NH2:28]参加物
6
実験手順
A solution of N-methylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5,6-difluoro-2-nitroaniline (1.0 eq) were heated at 90° C. for 1 hour. The reaction was allowed to cool to room temperature and then poured into water and let stand for 1 hour. The resulting solid was collected and dried and utilized without further purification. MH+=255.3
後処理
- customThe resulting solid was collected
- customdried
- customutilized without further purification
出典と根拠
- ORDレコード
- ord-d7843e8f4929497ebf753b95f50c5b6f
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07728010B2
反応ノート
読み込み中…