Piperazine → 1-(4-Methyl-1,3-thiazol-2-yl)piperazine
反応式
I[C:2]1[S:3][CH:4]=[C:5]([CH3:7])[N:6]=1.[NH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.C(N(CC)CC)C>O1CCCC1>[CH3:7][C:5]1[N:6]=[C:2]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[S:3][CH:4]=1参加物
5
反応条件
- 温度
- 160 °C
実験手順
A mixture of 1.33 mmol 2-iodo-4-methyl-thiazole, 4.00 mmol piperazine and 4.00 mmol triethylamine in 4 ml tetrahydrofuran in a sealed tube was heated at 160° C. for 2 h under microwave irradiation. The reaction mixture was concentrated and the residue was purified by chromatography (SiO2, methanol/dichloromethane) to afford the title compound as a yellow oil (yield 65%). MS (m/e): 184.3 (M+H+, 100%).
後処理
- concentrationThe reaction mixture was concentrated
- customthe residue was purified by chromatography (SiO2, methanol/dichloromethane)
出典と根拠
- ORDレコード
- ord-f84f7d0b5686488a8da39771159a8688
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07220744B2
反応ノート
読み込み中…