4-Chloroquinoline → 4-Methoxyquinoline

HRID 1352484ノート

反応式

HRID 1352484 の反応式
[CH3:1][O-:2].[Na+].Cl[C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][CH:6]=1>CO>[CH3:1][O:2][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 691404-ChloroquinolineHCID 10942334Sodium Methoxide

生成物 1

HCID 5219384-Methoxyquinoline収率 76%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of sodium methoxide (33 g) in methanol (130 ml), 4-chloroquinoline (10 g) was added under stirring. The mixture was heated under reflux for 6 hours. After cooling, the reaction mixture was concentrated, then dissolved in dichloromethane (250 ml) and washed with water (250 ml). The organic layer was dried over sodium sulfate. The solvent was evaporated to give a yellow oil (7.39 g, 76% yield) which was not purified.

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 6 hours
  3. temperatureAfter cooling
  4. concentrationthe reaction mixture was concentrated
  5. dissolutiondissolved in dichloromethane (250 ml)
  6. washwashed with water (250 ml)
  7. dry with materialThe organic layer was dried over sodium sulfate
  8. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-bec4131bde0f43f59b57d4718ce90a6c
出典データセット
uspto-grants-2007_05
特許番号
US07220760B2

反応ノート

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