Ethanol → 5,6-Dichloro-2-(4-carboxy-2-methoxyphenyl)benzimidazole

HRID 1352654ノート

反応式

HRID 1352654 の反応式
[Cl:1][C:2]1[C:20]([Cl:21])=[CH:19][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13]C(C#N)=[CH:11][C:10]=3[O:17][CH3:18])[NH:8][C:4]=2[CH:3]=1.[OH-:22].[Na+].[CH2:24]([OH:26])[CH3:25]>>[Cl:1][C:2]1[C:20]([Cl:21])=[CH:19][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:25]([C:24]([OH:22])=[O:26])=[CH:11][C:10]=3[O:17][CH3:18])[NH:8][C:4]=2[CH:3]=1

参加物

4

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 211011705,6-Dichloro-2-(4-cyano-2-methoxyphenyl)benzimidazole

生成物 1

HCID 211011665,6-Dichloro-2-(4-carboxy-2-methoxyphenyl)benzimidazole収率 46%

実験手順

A solution of 5,6-dichloro-2-(4-cyano-2-methoxyphenyl)benzimidazole, prepared as described in Preparation 5, in ethanol (50 ml) and 2N NaOH (15 ml) was refluxed for 16 h. Solvent was removed under reduced pressure and the residue was acidified with 37% HCl (10 ml), stirred for 1 h. The solid was filtered, washed with water (50 ml), dried at 50° C. under vacuum to give 0.92 g of the title compound (yield 46%), mp>250° C.

後処理

  1. customSolvent was removed under reduced pressure
  2. filtrationThe solid was filtered
  3. washwashed with water (50 ml)
  4. customdried at 50° C. under vacuum

出典と根拠

ORDレコード
ord-3445a8b6f87740ee933c94b4d448fb7d
出典データセット
uspto-grants-2007_05
特許番号
US07220769B2

反応ノート

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