Thionyl Chloride → 4-Chloro-5-chloroformyl-6-methoxy-2-methylthiopyrimidine
反応式
[Cl:1][C:2]1[C:7]([C:8](O)=[O:9])=[C:6]([O:11][CH3:12])[N:5]=[C:4]([S:13][CH3:14])[N:3]=1.S(Cl)([Cl:17])=O>>[Cl:1][C:2]1[C:7]([C:8]([Cl:17])=[O:9])=[C:6]([O:11][CH3:12])[N:5]=[C:4]([S:13][CH3:14])[N:3]=1参加物
3
反応条件
- 温度
- 40 °C
実験手順
A mixture of 4-chloro-5-carboxy-6-methoxy-2-methylthiopyrimidine (prepared in the above (3)) 2.00 g and thionyl chloride 5 ml is stirred at 40° C. for 15 minutes. Thionyl chloride, etc. is distilled off and the solvent is removed with azeotrope with methylene chloride to give 4-chloro-5-chloroformyl-6-methoxy-2-methylthiopyrimidine.
後処理
- distillationThionyl chloride, etc. is distilled off
- customthe solvent is removed with azeotrope with methylene chloride
出典と根拠
- ORDレコード
- ord-e22c99a56cd4495b801fa3f2c61e9e5b
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07220736B2
反応ノート
読み込み中…