Thiophosgene → 3-Phenoxyphenylisothiocyanate
反応式
[O:1]([C:8]1[CH:9]=[C:10]([CH:12]=[CH:13][CH:14]=1)[NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15](Cl)(Cl)=[S:16].CCCCCC.CCOC(C)=O>CC(C)=O>[O:1]([C:8]1[CH:9]=[C:10]([N:11]=[C:15]=[S:16])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
5
実験手順
To a stirring solution of 3-phenoxyaniline (185 mg, 1.0 mmol) in acetone (4.0 mL) at 0° C. was added thiophosgene (0.23 mL, 3.0 mmol) and the resulting reaction maintained for 30 min. The reaction determined complete by TLC (4:1 hexane/EtOAc). The reaction was concentrated, azeotroped with toluene and taken on without further purification.
後処理
- customthe resulting reaction
- temperaturemaintained for 30 min
- concentrationThe reaction was concentrated
- customazeotroped with toluene
- customtaken on without further purification
出典と根拠
- ORDレコード
- ord-b272333b6f17485f927833b273755ad7
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07728010B2
反応ノート
読み込み中…