Thiophosgene → 3-Phenoxyphenylisothiocyanate

HRID 13530

反応式

HRID 13530 の反応式
[O:1]([C:8]1[CH:9]=[C:10]([CH:12]=[CH:13][CH:14]=1)[NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15](Cl)(Cl)=[S:16].CCCCCC.CCOC(C)=O>CC(C)=O>[O:1]([C:8]1[CH:9]=[C:10]([N:11]=[C:15]=[S:16])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 10040ThiophosgeneHCID 771353-PhenoxyanilineHCID 21226206Ethyl acetate hexane

生成物 1

HCID 220412813-Phenoxyphenylisothiocyanate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a stirring solution of 3-phenoxyaniline (185 mg, 1.0 mmol) in acetone (4.0 mL) at 0° C. was added thiophosgene (0.23 mL, 3.0 mmol) and the resulting reaction maintained for 30 min. The reaction determined complete by TLC (4:1 hexane/EtOAc). The reaction was concentrated, azeotroped with toluene and taken on without further purification.

後処理

  1. customthe resulting reaction
  2. temperaturemaintained for 30 min
  3. concentrationThe reaction was concentrated
  4. customazeotroped with toluene
  5. customtaken on without further purification

出典と根拠

ORDレコード
ord-b272333b6f17485f927833b273755ad7
出典データセット
uspto-grants-2010_06
特許番号
US07728010B2

関連ノート

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