Methyl iodide → HCID 11271869、化合物

HRID 1353084ノート

反応式

HRID 1353084 の反応式
C[O:2][C:3]([C:5]1[S:6][C:7]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:8][C:9]=1[NH:10][C:11]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[C:16]([O:28][CH3:29])[CH:15]=1)=[S:12])=O.[C:36](=O)([O-])[O-].[K+].[K+].CI>CN(C=O)C>[CH3:29][O:28][C:16]1[CH:15]=[C:14]([N:13]2[C:3](=[O:2])[C:5]3[S:6][C:7]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)=[CH:8][C:9]=3[N:10]=[C:11]2[S:12][CH3:36])[CH:19]=[CH:18][C:17]=1[O:20][CH2:21][CH2:22][N:23]1[CH2:24][CH2:25][CH2:26][CH2:27]1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 11214411HCID 11214411、化合物

生成物 1

HCID 11271869HCID 11271869、化合物収率 50%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

This ester (300 mg, 0.56 mmol) and potassium carbonate (162 mg, 1.17 mmol) were suspended in dry DMF (5 ml) and treated with a solution of methyl iodide (83 mg, 0.59 mmol) in DMF (1 ml). When the addition was complete, the mixture was evaporated. The residue was purified by chromatography on silica gel (eluting with dichloromethane-methanol) giving the title compound in 50% yield;

後処理

  1. additionWhen the addition
  2. customthe mixture was evaporated
  3. customThe residue was purified by chromatography on silica gel (eluting with dichloromethane-methanol)

出典と根拠

ORDレコード
ord-b55445fd8de5432b9586c1601ace5fe7
出典データセット
uspto-grants-2007_05
特許番号
US07220777B2

反応ノート

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