Water → Ethyl (2-formamido-5-chlorothiazol-4-yl)glyoxylate

HRID 13532

反応式

HRID 13532 の反応式
[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:8]=1)=[O:2].[Cl:16]N1C(=O)CCC1=O.O>CN(C=O)C>[CH:1]([NH:3][C:4]1[S:5][C:6]([Cl:16])=[C:7]([C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:8]=1)=[O:2]

参加物

5

反応物 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 2733245Ethyl 2-(formylamino)-alpha-oxo-4-thiazoleacetate

生成物 1

HCID 14326717Ethyl (2-formamido-5-chlorothiazol-4-yl)glyoxylate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Ethyl 2-(Formylaminothiazol-4-yl)-2-oxoacetate (9.1 g, 39.87 mmol) (obtained from Aldrich, Milwaukee, Wis.) was slurried in 50 mL of anhydrous DMF. N-Chlorosuccinimide (5.6 g, 41.86 mmol) was added as a solid and the suspension was stirred at room temperature. After 18 hours, the reaction mixture was poured into 500 mL of water. The resulting white precipitate was filtered, washed with water and air dried to afford the title intermediate as a white solid.

後処理

  1. filtrationThe resulting white precipitate was filtered
  2. washwashed with water and air
  3. customdried

出典と根拠

ORDレコード
ord-572aaac4a1614a098cd42dd318d131d2
出典データセット
uspto-grants-2010_06
特許番号
US07728127B2

関連ノート

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