Trifluoroacetic acid → (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

HRID 1353206ノート

反応式

HRID 1353206 の反応式
[CH2:1]([O:3][C:4](=[O:24])[C@@H:5]([O:22][CH3:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]([O:17]C(C)(C)C)=[O:16])=[CH:9][CH:8]=1)[CH3:2].FC(F)(F)C(O)=O>ClCCl>[CH2:1]([O:3][C:4](=[O:24])[C@@H:5]([O:22][CH3:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:9][CH:8]=1)[CH3:2]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 58864672(2S)-3-(4-tert-butoxycarbonylmethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

生成物 1

HCID 58864673(2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The compound of (2S)-3-(4-tert-butoxycarbonylmethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (PREPARATION 3, step 1) (1.2 gr, 3.5 mmol) was solved in dichloromethane (5 ml) and trifluoroacetic acid was added (5 ml). The mixture was stirred for an hour, and the crude was concentrated to afford a yellow oil. 1H-NMR (CDCl3, 200.15 MHz): 7.16 (d, 2H, J=8.3), 6.75 (d, 2H, J=8.3), 4.89 (s, 2H), 4.14 (c, 2H, J=6.9), 3.94 (t, 1H, J=6.9), 3.57 (dc, 1H), 3.35 (dc, 1H), 2.92 (d, 2H, J=6.9), 1.23-1.10 (2t, 6H).

後処理

  1. concentrationthe crude was concentrated
  2. customto afford a yellow oil

出典と根拠

ORDレコード
ord-222c882ec02b41f2b048d8883f0c32e5
出典データセット
uspto-grants-2007_05
特許番号
US07220880B2

反応ノート

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