Diisopropylethylamine → 4-(7-Chloro-4-quinolinyl)-N-(2,3-dimethylcyclohexyl)-1-piperazinecarboxamide

HRID 1353412

反応式

[CH3:1][CH:2]1[CH:7]([CH3:8])[CH2:6][CH2:5][CH2:4][CH:3]1[NH2:9].Cl[C:11](OC1C=CC([N+]([O-])=O)=CC=1)=[O:12].C(N(C(C)C)CC)(C)C.[Cl:32][C:33]1[CH:42]=[C:41]2[C:36]([C:37]([N:43]3[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]3)=[CH:38][CH:39]=[N:40]2)=[CH:35][CH:34]=1>C(Cl)Cl.CO>[Cl:32][C:33]1[CH:42]=[C:41]2[C:36]([C:37]([N:43]3[CH2:48][CH2:47][N:46]([C:11]([NH:9][CH:3]4[CH2:4][CH2:5][CH2:6][CH:7]([CH3:8])[CH:2]4[CH3:1])=[O:12])[CH2:45][CH2:44]3)=[CH:38][CH:39]=[N:40]2)=[CH:35][CH:34]=1

参加物

実験手順

As described for example 78, 2,3-dimethyl-cyclohexanamine (154 mg, 1.21 mmol), 4-nitrophenyl chloroformate (244 mg, 1.21 mmol), diisopropyl(ethyl)amine (209 mg, 1.62 mmol), and 7-chloro-4-(piperazin-1-yl)quinoline (200 mg, 0.81 mmol) are reacted affording the title product after flash chromatography with CH2Cl2-MeOH. 1H NMR (DSMO-d6) δ 0.7–0.9 (m, 7H), 1.13–1.92 (m, 8H), 3.2 (m, 1H), 3.6 (br. s, 4H), 3.9 (br. s, 4H), 7.2 (m, 1H), 7.7 (m, 1H), 8.0 (s, 1H), 8.2 (m, 1H), 8.6 (m, 1H).

後処理

customare reacted

出典と根拠

ORDレコード: ord-56d69cdaf8284c3a8e68099ae5b45b0d
出典データセット: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07220856B2

反応式

参加物

反応物 4

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

関連ノート