8-(6-Methoxy-[1,5]naphthyridin-4-ylethynyl)-1,4-dioxa-spiro[4.5]decan-8-ol → 8-[2-(6-Methoxy-[1,5]naphthyridin-4-yl)ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol

HRID 1354212ノート

反応式

HRID 1354212 の反応式
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[C:13]#[C:14][C:15]1([OH:25])[CH2:24][CH2:23][C:18]2([O:22][CH2:21][CH2:20][O:19]2)[CH2:17][CH2:16]1.[H][H]>C(O)C.O=[Pt]=O>[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[CH2:13][CH2:14][C:15]1([OH:25])[CH2:16][CH2:17][C:18]2([O:22][CH2:21][CH2:20][O:19]2)[CH2:23][CH2:24]1

参加物

5

反応物 2

HCID 211046678-(6-Methoxy-[1,5]naphthyridin-4-ylethynyl)-1,4-dioxa-spiro[4.5]decan-8-olHCID 178418361HCID 178418361、化合物

生成物 1

HCID 211046648-[2-(6-Methoxy-[1,5]naphthyridin-4-yl)ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

A solution of 8-(6-methoxy-[1,5]naphthyridin-4-ylethynyl)-1,4-dioxa-spiro[4.5]decan-8-ol (965 mg, 2.8 mmol) in ethanol (100 ml) was hydrogenated for 6 hours over PtO2 (200 mg) at 1 bar of hydrogen. The catalyst was filtered off and replaced by fresh catalyst and the hydrogenation was continued for a further 3 hours. The catalyst was filtered off and the solvent was concentrated. The crude product was purified by chromatography on silica gel (EtOAc).

後処理

  1. filtrationThe catalyst was filtered off
  2. filtrationThe catalyst was filtered off
  3. concentrationthe solvent was concentrated
  4. customThe crude product was purified by chromatography on silica gel (EtOAc)

出典と根拠

ORDレコード
ord-1c93d1b9bbd54b3ba19702f2923804ce
出典データセット
uspto-grants-2007_05
特許番号
US07223776B2

反応ノート

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