HCID 21104706、化合物 → HCID 21104576、化合物
反応式
[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][NH:12][CH2:13][C:14]3[CH2:19][N:18](NC(OC(C)(C)C)=O)[CH2:17][CH2:16][CH:15]=3)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1>C(O)(C(F)(F)F)=O>[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][NH:12][CH2:13][C:14]3[CH2:19][NH:18][CH2:17][CH2:16][CH:15]=3)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1参加物
3
実験手順
A solution of tert-butyl 5-{[(2,3-dihydro-benzo[1,4]-dioxin-6-ylmethyl)-amino]-methyl}-3,6-dihydro-2H-pyridine-1-carbamate (0.16 g, 0.44 mmol) in TFA (3 ml) was stirred at room temperature for 30 minutes, concentrated and taken up in saturated bicarbonate solution (30 ml) and dichloromethane (30 ml). The aqueous phase was extracted with dichloromethane (2×30 ml) and the combined organic phases were washed with saturated sodium chloride solution, dried over MgSO4 and concentrated.
後処理
- concentrationconcentrated
- extractionThe aqueous phase was extracted with dichloromethane (2×30 ml)
- washthe combined organic phases were washed with saturated sodium chloride solution