Sodium borohydride → Tert-butyl 2-hydroxy-2-(pyridin-3-yl)ethylcarbamate

HRID 1354403ノート

反応式

HRID 1354403 の反応式
[O:1]=[C:2]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8].[BH4-].[Na+]>C(O)C>[OH:1][CH:2]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 58993194tert-Butyl (2-oxo-2-(pyridin-3-yl)ethyl)carbamate

生成物 1

HCID 19351381Tert-butyl 2-hydroxy-2-(pyridin-3-yl)ethylcarbamate収率 103%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of the product from step (b) (1.30 g) in ethanol (50 ml) was added sodium borohydride (105 mg). The mixture was stirred for 1.5 h then evaporated. Water was added and the mixture extracted twice with ethyl acetate. The combined organic layers were washed (brine) and dried (MgSO4). The solvent was evaporated off to give the sub-title compound (1.35 g) as an oil.

後処理

  1. customthen evaporated
  2. additionWater was added
  3. extractionthe mixture extracted twice with ethyl acetate
  4. washThe combined organic layers were washed (brine)
  5. dry with materialdried (MgSO4)
  6. customThe solvent was evaporated off

出典と根拠

ORDレコード
ord-822bfe8892a74c148d6c5ff5b093b398
出典データセット
uspto-grants-2007_05
特許番号
US07223794B2

反応ノート

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