1,1'-Carbonyldiimidazole → tert-Butyl [1-(4-{[4-(4-Chlorophenyl)piperidin-1-carbonyl]amino}-phenyl)azetidin-3-yl]methylcarbamate
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:11][CH:10]([CH2:12][NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH2:9]2)=[CH:4][CH:3]=1.[C:21]([N:28]1[CH:32]=[CH:31]N=[CH:29]1)(N1C=CN=C1)=[O:22].[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([CH:40]2CCNC[CH2:41]2)=[CH:36][CH:35]=1>>[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([CH:40]2[CH2:41][CH2:29][N:28]([C:21]([NH:1][C:2]3[CH:7]=[CH:6][C:5]([N:8]4[CH2:9][CH:10]([CH2:12][NH:13][C:14](=[O:20])[O:15][C:16]([CH3:17])([CH3:19])[CH3:18])[CH2:11]4)=[CH:4][CH:3]=3)=[O:22])[CH2:32][CH2:31]2)=[CH:36][CH:35]=1参加物
4
実験手順
tert-Butyl [1-(4-aminophenyl)azetidin-3-yl]methylcarbamate was reacted with carbonyldiimidazole and 4-(4-chlorophenyl)piperidine by method A. This resulted in the product with the molecular weight of 499.06 (C27H35ClN4O3; MS (ESI): 499 (M+H+).