3-(4-Benzyloxyphenyl)-2-ethoxypropanoic acid ethyl ester → Ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate

HRID 1354888ノート

反応式

HRID 1354888 の反応式
[CH2:1]([O:3][CH:4]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17]CC2C=CC=CC=2)=[CH:13][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:2].[H][H]>[Pd].S1CCOCC1>[CH2:1]([O:3][CH:4]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([OH:17])=[CH:15][CH:16]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:2]

参加物

5

反応物 2

HCID 110779683-(4-Benzyloxyphenyl)-2-ethoxypropanoic acid ethyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 11791243Ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate収率 97%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 275961,4-Oxathiane溶媒

実験手順

A mixture of racemic ethyl 2oxy-3-(4-benzyloxyphenyl)propionate of the formula (12a) (40 g) obtained according to the procedure described in step (iv) above, 5% Pd/C catalyst (8 g) and 1,4-thioxane (200 ml) was subjected to hydrogenation at room temperature and 50–60 psi of hydrogen pressure for a period of 8–12 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the catalyst was filtered off and the solvent was removed under reduced pressure to afford the title compound of the formula (13a) (28–29 g, 97–98%).,

後処理

  1. customobtained
  2. customwas subjected to hydrogenation at room temperature
  3. customAfter completion of the reaction
  4. filtrationthe catalyst was filtered off
  5. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-b8e5f116950147cf9a865c6a834c27c4
出典データセット
uspto-grants-2007_05
特許番号
US07223881B2

反応ノート

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