1,8-Diazabicyclo(5.4.0)undec-7-ene → 2-Amino-4-furan-2-yl-6-[(5-methyl-pyridin-2-ylmethyl)-amino]-pyrimidine-5-carbonitrile

反応式

[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](S(C)=O)[N:3]=1.Cl.Cl.[CH3:20][C:21]1[CH:22]=[CH:23][C:24]([CH2:27][NH2:28])=[N:25][CH:26]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4]([NH:28][CH2:27][C:24]2[CH:23]=[CH:22][C:21]([CH3:20])=[CH:26][N:25]=2)[N:3]=1

参加物

実験手順

From 2-amino-4-furan-2-yl-6-methanesulfinyl-pyrimidine-5-carbonitrile, C-(5-methyl-pyridin-2-yl)-methylamine dihydrochloride and DBU in DME. ES-MS m/e (%): 307 (M+H+, 100).

出典と根拠

ORDレコード: ord-17bf196a8801494e8e1dd5fe65aa7383
出典データセット: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06586441B2

反応ノート

読み込み中…

参加物

反応物 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

HCID 18507448(5-Methylpyridin-2-yl)methanamine dihydrochloride

HCID 185076922-Amino-4-(furan-2-YL)-6-(methylsulfinyl)pyrimidine-5-carbonitrile

生成物 1

HCID 98150312-Amino-4-furan-2-yl-6-[(5-methyl-pyridin-2-ylmethyl)-amino]-pyrimidine-5-carbonitrile

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

実験手順

From 2-amino-4-furan-2-yl-6-methanesulfinyl-pyrimidine-5-carbonitrile, C-(5-methyl-pyridin-2-yl)-methylamine dihydrochloride and DBU in DME. ES-MS m/e (%): 307 (M+H+, 100).

出典と根拠

ORDレコード: ord-17bf196a8801494e8e1dd5fe65aa7383
出典データセット: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06586441B2

反応ノート

読み込み中…