Potassium Carbonate → 2-Amino-4-(2-fluoro-phenyl)-6-methylsulfanyl-pyrimidine-5-carbonitrile

HRID 1356052

反応式

HRID 1356052 の反応式
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([C:9]#[N:10])=[C:4]([S:11][CH3:12])[N:3]=1.[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1B(O)O.C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Pd]>[NH2:1][C:2]1[N:7]=[C:6]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[F:13])[C:5]([C:9]#[N:10])=[C:4]([S:11][CH3:12])[N:3]=1

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 27343542-Fluorophenylboronic acidHCID 185072602-Amino-4-chloro-6-methylsulfanyl-pyrimidine-5-carbonitrile

生成物 1

HCID 185076272-Amino-4-(2-fluoro-phenyl)-6-methylsulfanyl-pyrimidine-5-carbonitrile

試薬・触媒・溶媒 2

HCID 11979704Tetrakis(triphenylphosphine)palladium触媒HCID 1140Toluene溶媒

実験手順

From 2-amino-4-chloro-6-methylsulfanyl-pyrimidine-5-carbonitrile, o-fluorobenzeneboronic acid, tetrakis(triphenylphosphine)palladium(O) and potassium carbonate in toluene. ES-MS m/e (%): 261 (M+H+, 100).

出典と根拠

ORDレコード
ord-fe6a1f5921b844e48ae0701f58d91a8d
出典データセット
uspto-grants-2003_07
特許番号
US06586441B2

関連ノート

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