(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methanamine → 2-Amino-4-[(3-chloro-5-trifluoromethyl-pyridin-2-yl-methyl)-amino]-6-(4-methyl-furan-2-yl)-pyrimidine-5-carbonitrile

HRID 1356082ノート

反応式

HRID 1356082 の反応式
[NH2:1][C:2]1[N:7]=[C:6](S(C)=O)[C:5]([C:11]#[N:12])=[C:4]([C:13]2[O:14][CH:15]=[C:16]([CH3:18])[CH:17]=2)[N:3]=1.[NH2:19][CH2:20][C:21]1[C:26]([Cl:27])=[CH:25][C:24]([C:28]([F:31])([F:30])[F:29])=[CH:23][N:22]=1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([NH:19][CH2:20][C:21]2[C:26]([Cl:27])=[CH:25][C:24]([C:28]([F:31])([F:30])[F:29])=[CH:23][N:22]=2)[C:5]([C:11]#[N:12])=[C:4]([C:13]2[O:14][CH:15]=[C:16]([CH3:18])[CH:17]=2)[N:3]=1

参加物

4

反応物 2

HCID 11085087(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methanamineHCID 185075602-Amino-4-methanesulfinyl-6-(4-methyl-furan-2-yl)-pyrimidine-5-carbonitrile

生成物 1

HCID 185074132-Amino-4-[(3-chloro-5-trifluoromethyl-pyridin-2-yl-methyl)-amino]-6-(4-methyl-furan-2-yl)-pyrimidine-5-carbonitrile

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

実験手順

From 2-amino-4-methanesulfinyl-6-(4-methyl-furan-2-yl)-pyrimidine-5-carbonitrile and 2-aminomethyl-3-chloro-5-(trifluoromethyl)pyridine in DME. ES-MS m/e (%): 411 (M{37Cl}+H+, 35), 409 (M{35Cl}+H+, 100).

出典と根拠

ORDレコード
ord-a2007de0610d4081a4345793430aade1
出典データセット
uspto-grants-2003_07
特許番号
US06586441B2

反応ノート

読み込み中…