1,8-Diazabicyclo(5.4.0)undec-7-ene → 2-Amino-4-(3-methyl-pyridin-2-ylmethoxy)-6-pyrazol-1-yl-pyrimidine-5-carbonitrile

HRID 1356135

反応式

HRID 1356135 の反応式
[NH2:1][C:2]1[N:7]=[C:6](S(C)=O)[C:5]([C:11]#[N:12])=[C:4]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)[N:3]=1.[CH3:18][C:19]1[C:20]([CH2:25][OH:26])=[N:21][CH:22]=[CH:23][CH:24]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([O:26][CH2:25][C:20]2[C:19]([CH3:18])=[CH:24][CH:23]=[CH:22][N:21]=2)[C:5]([C:11]#[N:12])=[C:4]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)[N:3]=1

参加物

5

反応物 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 1514369(3-Methylpyridin-2-yl)methanolHCID 185075202-Amino-4-methanesulfinyl-6-pyrazol-1-yl-pyrimidine-5-carbonitrile

生成物 1

HCID 185074012-Amino-4-(3-methyl-pyridin-2-ylmethoxy)-6-pyrazol-1-yl-pyrimidine-5-carbonitrile

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

実験手順

From 2-amino-4-methanesulfinyl-6-pyrazol-1-yl-pyrimidine-5-carbonitrile, 3-methyl-2-pyridinemethanol and DBU in DME. ES-MS m/e (%): 308 (M+H+, 100).

出典と根拠

ORDレコード
ord-73da989ecd1d49de90e4641bdacff0ef
出典データセット
uspto-grants-2003_07
特許番号
US06586441B2

関連ノート

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