1,8-Diazabicyclo(5.4.0)undec-7-ene → 2-Amino-4-(4-bromo-furan-2-yl)-6-(3-methyl-pyridin-2-yl-methoxy)-pyrimidine-5-carbonitrile

反応式

[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[C:11]([Br:13])[CH:12]=2)[C:5]([C:14]#[N:15])=[C:4](S(C)=O)[N:3]=1.[CH3:19][C:20]1[C:21]([CH2:26][OH:27])=[N:22][CH:23]=[CH:24][CH:25]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[C:11]([Br:13])[CH:12]=2)[C:5]([C:14]#[N:15])=[C:4]([O:27][CH2:26][C:21]2[C:20]([CH3:19])=[CH:25][CH:24]=[CH:23][N:22]=2)[N:3]=1

参加物

実験手順

From 2-amino-4-(4-bromo-furan-2-yl)-6-methanesulfinyl-pyrimidine-5-carbonitrile, 3-methyl-2-pyridinemethanol and DBU in DME. ES-MS m/e (%): 388 (M{81Br}+H+, 100), 386 (M{79Br}+H+, 80).

出典と根拠

ORDレコード: ord-989a5a1685864e53aa0dc4cda2e710f2
出典データセット: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06586441B2

反応ノート

読み込み中…

参加物

反応物 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

HCID 1514369(3-Methylpyridin-2-yl)methanol

HCID 185074982-Amino-4-(4-bromo-furan-2-yl)-6-methanesulfinyl-pyrimidine-5-carbonitrile

生成物 1

HCID 102934932-Amino-4-(4-bromo-furan-2-yl)-6-(3-methyl-pyridin-2-yl-methoxy)-pyrimidine-5-carbonitrile

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

実験手順

From 2-amino-4-(4-bromo-furan-2-yl)-6-methanesulfinyl-pyrimidine-5-carbonitrile, 3-methyl-2-pyridinemethanol and DBU in DME. ES-MS m/e (%): 388 (M{81Br}+H+, 100), 386 (M{79Br}+H+, 80).

出典と根拠

ORDレコード: ord-989a5a1685864e53aa0dc4cda2e710f2
出典データセット: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06586441B2

反応ノート

読み込み中…