3-Methylcatechol → 4-Methyl-1,3-benzodioxole

HRID 1356895

反応式

HRID 1356895 の反応式
Br[CH2:2]Br.[CH3:4][C:5]1[CH:11]=[CH:10][CH:9]=[C:7]([OH:8])[C:6]=1[OH:12]>CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)C.[Cl-].O>[CH3:4][C:5]1[C:6]2[O:12][CH2:2][O:8][C:7]=2[CH:9]=[CH:10][CH:11]=1

参加物

5

反応物 2

HCID 3403-MethylcatecholHCID 3024Dibromomethane

生成物 1

HCID 885604-Methyl-1,3-benzodioxole

試薬・触媒・溶媒 2

HCID 21218Trioctylmethylammonium chloride触媒HCID 962Water溶媒

実験手順

11.6 g Adogen 464 and 7 mL of dibromomethane were refluxed in 50 mL of H2O for 0.5 hours under argon. 3-Methylcatechol (8.89 g, 71.6 mmol) was added over 2 hours and the mixture refluxed for an additional 1 hour. Distillation of the product from the reaction mixture afforded the title compound as a yellow oil: HRMS m/e 136.0524 (calc'd for C8H8O2, 136.0524).

後処理

  1. temperaturethe mixture refluxed for an additional 1 hour
  2. distillationDistillation of the product from the reaction mixture

出典と根拠

ORDレコード
ord-50b1e9813d424447b29a3271e6080318
出典データセット
uspto-grants-2003_07
特許番号
US06586603B1

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