Methanol → Methyl 1-benzofuran-2-carboxylate

HRID 1357178

反応式

HRID 1357178 の反応式
S(Cl)(Cl)=O.[O:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH:7]=[C:6]1[C:14]([OH:16])=[O:15].[CH3:17]O>>[O:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH:7]=[C:6]1[C:14]([O:16][CH3:17])=[O:15]

参加物

4

反応物 3

HCID 887MethanolHCID 10331Benzofuran-2-carboxylic acidHCID 24386Thionyl Chloride

生成物 1

HCID 291153Methyl 1-benzofuran-2-carboxylate

実験手順

After adding thionyl chloride (3.80 ml) to a solution of 2-benzofurancarboxylic acid (2.00 g) in MeOH (60 ml) at −40° C., the mixture was stirred for 19 hours while the temperature gradually increased to room temperature. The reaction solution was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (n-hexane/AcOEt=6/1) to obtain methyl 2-benzofurancarboxylate.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (n-hexane/AcOEt=6/1)

出典と根拠

ORDレコード
ord-5f4526a0eb564e81b5579c84793da54b
出典データセット
uspto-grants-2003_07
特許番号
US06589984B1

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