Methyl iodide → Methyl 2-methyl-3-oxopentanoate

HRID 1357179

反応式

HRID 1357179 の反応式
CI.[C:3]([O-])([O-])=O.[K+].[K+].[C:9]([CH2:13][C:14]([O:16][CH3:17])=[O:15])(=[O:12])[CH2:10][CH3:11]>CC(C)=O>[CH3:3][CH:13]([C:9](=[O:12])[CH2:10][CH3:11])[C:14]([O:16][CH3:17])=[O:15]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 121699Methyl 3-oxovalerate

生成物 1

HCID 545860Methyl 2-methyl-3-oxopentanoate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Methyl iodide (57 ml) and K2CO3 (127 g) were added to a solution of methyl propionylacetate (100 g) in acetone (800 ml) while cooling on ice. The reaction solution was stirred for 96 hours at room temperature and celite filtered, and then the mother liquor was slowly concentrated under reduced pressure and distilled under reduced pressure to obtain methyl 2-methyl-3-oxopentanoate.

後処理

  1. temperaturewhile cooling on ice
  2. filtrationcelite filtered
  3. concentrationthe mother liquor was slowly concentrated under reduced pressure
  4. distillationdistilled under reduced pressure

出典と根拠

ORDレコード
ord-d36bac8f934f4ab9af43a8e39619584d
出典データセット
uspto-grants-2003_07
特許番号
US06589984B1

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