Oxalic Acid → HCID 87877562、化合物

反応式

C(OC([NH:11][C@H:12]([C:16]([NH:18][C@H:19]([C:21]([O:23][CH3:24])=[O:22])[CH3:20])=[O:17])[CH:13]([CH3:15])[CH3:14])=O)C1C=CC=CC=1.[C:25]([OH:30])(=[O:29])[C:26]([OH:28])=[O:27]>CO.[Pd]>[C:25]([OH:30])(=[O:29])[C:26]([OH:28])=[O:27].[NH2:11][C@H:12]([C:16]([NH:18][C@H:19]([C:21]([O:23][CH3:24])=[O:22])[CH3:20])=[O:17])[CH:13]([CH3:15])[CH3:14]

参加物

実験手順

2.69 g (8.0 mmol) of methyl benzyloxycarbonyl-L-valyl-L-alaninate [E. Klieger and E. Schr{overscore (o)}der: Ann. Chem. 661, 193 (1963)] are dissolved in 25 ml of methanol, 0.72 9 (8.0 mmol) of anhydrous oxalic acid and 0.1 g of Pd/C catalyst are added, then the mixture is submitted to hydrogenation at about 20° C. The catalyst is filtered off and the filtrate is evaporated at a pressure of 2.0-2.5 kPa. The crystalline residue is rubbed with diethyl ether, filtered, washed with diethyl ether and dried in a vacuum desiccator.