Triethylamine → HCID 131723975、化合物
反応式
[S:1](Cl)(Cl)=[O:2].O[C@:6]1([C:16]([O:18][CH3:19])=[O:17])[CH2:11][C@@H:10]([CH:12]=[CH2:13])[C@H:9]([OH:14])[C@H:8]([OH:15])[CH2:7]1.C(N(CC)CC)C>ClCCl>[CH:12]([C@H:10]1[C@@H:9]2[O:14][S:1](=[O:2])[O:15][C@@H:8]2[CH:7]=[C:6]([C:16]([O:18][CH3:19])=[O:17])[CH2:11]1)=[CH2:13]参加物
5
実験手順
Thionyl chloride can be added dropwise to a 0° C. solution of Example 17F and triethylamine in dichloromethane. After stirring for 30 minutes, the reaction mixture can be washed with saturated NaHCO3 solution, and brine, dried (MgSO4) filtered and concentrated to afford the crude desired product.
後処理
- washthe reaction mixture can be washed with saturated NaHCO3 solution, and brine
- dry with materialdried (MgSO4)
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-ddd6e50730c24dbba600a78129067b7e
- 出典データセット
- uspto-grants-2003_07
- 特許番号
- US06593314B1
反応ノート
読み込み中…