Nitric Acid → HCID 54161804、化合物

HRID 1357856

反応式

HRID 1357856 の反応式
[C:1]1([C@H:7]([CH3:12])[CH2:8][C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(=O)(=O)(O)O.[N+:18]([O-])([OH:20])=[O:19]>O>[N+:18]([C:4]1[CH:5]=[CH:6][C:1]([C@H:7]([CH3:12])[CH2:8][C:9]([OH:11])=[O:10])=[CH:2][CH:3]=1)([O-:20])=[O:19]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 852992(3R)-3-phenylbutanoic acid

生成物 1

HCID 54161804HCID 54161804、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

(R)-3-phenylbutanoic acid (10.0 g) was added to concentrated sulphuric acid (40 mL) at −5° C. under nitrogen. The resulting thick gel-like mixture was stirred vigorously and fuming nitric acid (2.8 mL) was added slowly over 20 minutes. The reaction mixture was poured onto a mixture of ice and water (500 mL) and the resulting white precipitate was collected by filtration, then washed thoroughly with water, and then dried to give the title compound (10.1 g) as a white solid.

後処理

  1. filtrationthe resulting white precipitate was collected by filtration
  2. washwashed thoroughly with water
  3. customdried

出典と根拠

ORDレコード
ord-9f4a8f80140440f19ca0f2accf3509d4
出典データセット
uspto-grants-2003_07
特許番号
US06593354B2

関連ノート

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