Methyl 3-hydroxy-5-methoxy-4-nitrophenylacetate → Methyl 4-amino-3-hydroxy-5-methoxy-phenylacetate

HRID 1357862ノート

反応式

HRID 1357862 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH:5]=[C:6]([O:11][CH3:12])[C:7]=1[N+:8]([O-])=O>C(O)C.[Pd]>[NH2:8][C:7]1[C:6]([O:11][CH3:12])=[CH:5][C:4]([CH2:13][C:14]([O:16][CH3:17])=[O:15])=[CH:3][C:2]=1[OH:1]

参加物

4

反応物 1

HCID 18188097Methyl 3-hydroxy-5-methoxy-4-nitrophenylacetate

生成物 1

HCID 18188079Methyl 4-amino-3-hydroxy-5-methoxy-phenylacetate収率 100.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of methyl 3-hydroxy-5-methoxy-4-nitrophenylacetate (0.34 g, Reference Example 11) in ethanol (25 mL) was treated with palladium on charcoal (approximately 0.035 g, 10%) and stirred under a hydrogen atmosphere. After 2 hours the mixture was filtered through a pad of celite and the filtrate was evaporated to give the title compound (0.3 g ) as a brown oil.

後処理

  1. filtrationAfter 2 hours the mixture was filtered through a pad of celite
  2. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-6df3da697a494f0e9ba9556c97cfb797
出典データセット
uspto-grants-2003_07
特許番号
US06593354B2

反応ノート

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