Diisopropylethylamine → HCID 57226830、化合物

HRID 1357866ノート

反応式

HRID 1357866 の反応式
[CH3:1][C:2]1[C:7]2[N:8]=[C:9]([NH:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[CH3:18])[O:10][C:6]=2[CH:5]=[C:4]([CH2:19][C:20](O)=[O:21])[CH:3]=1.F[P-](F)(F)(F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2N=CC=CC=2N=N1.C(N(C(C)C)CC)(C)C.[NH2:56][C:57]1[CH:62]=[CH:61][C:60]([C@H:63]([CH3:70])[CH2:64][C:65]([O:67][CH2:68][CH3:69])=[O:66])=[CH:59][CH:58]=1>CN(C)C=O.C(OCC)(=O)C>[CH3:1][C:2]1[C:7]2[N:8]=[C:9]([NH:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[CH3:18])[O:10][C:6]=2[CH:5]=[C:4]([CH2:19][C:20]([NH:56][C:57]2[CH:58]=[CH:59][C:60]([C@H:63]([CH3:70])[CH2:64][C:65]([O:67][CH2:68][CH3:69])=[O:66])=[CH:61][CH:62]=2)=[O:21])[CH:3]=1

参加物

7

反応物 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 18188094(4-Methyl-2-o-tolylamino-benzoxazol-6-yl)-acetic acidHCID 53963459HCID 53963459、化合物

生成物 1

HCID 57226830HCID 57226830、化合物収率 91.5%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A stirred solution of 2-(4-methyl-2-o-tolylaminobenzoxazol-6-yl)acetic acid [0.1 g, Reference Example 9(b)] in dimethylformamide (3 mL) was treated with O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (0.128 g), diisopropylethylamine (0.22 g) and after 5 minutes with ethyl (R) 3-(4-aminophenyl)butanoate (0.107 g, Reference Example 1). After 4 hours the reaction mixture was diluted with ethyl acetate and then washed with water, then with hydrochloric acid (1M), then twice with water, then with brine, then dried and then evaporated to give the title compound (0.15 g) as a brown oil.

後処理

  1. washwashed with water
  2. dry with materialwith hydrochloric acid (1M), then twice with water, then with brine, then dried
  3. customevaporated

出典と根拠

ORDレコード
ord-d7ff232d3e9f4cb684f412885bcfbc24
出典データセット
uspto-grants-2003_07
特許番号
US06593354B2

反応ノート

読み込み中…