Lithium Hydroxide → HCID 18188087、化合物

HRID 1357867ノート

反応式

HRID 1357867 の反応式
C([O:4][C:5]1[CH:6]=[C:7]([CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:8]=[C:9]([CH3:14])[C:10]=1[N+:11]([O-:13])=[O:12])(=O)C.[OH-].[Li+].C(OCC)(=O)C.[Cl-].[Na+]>CO.O>[OH:4][C:5]1[CH:6]=[C:7]([CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:8]=[C:9]([CH3:14])[C:10]=1[N+:11]([O-:13])=[O:12]

参加物

7

反応物 4

HCID 3939Lithium HydroxideHCID 5234Sodium ChlorideHCID 8857Ethyl AcetateHCID 18188096t-Butyl 3-acetoxy-5-methyl-4-nitrophenylacetate

生成物 1

HCID 18188087HCID 18188087、化合物収率 104.2%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution of t-butyl 3-acetoxy-5-methyl-4-nitrophenylacetate [0.5 g, Reference Example 17(a)] in methanol (6 mL) was treated with lithium hydroxide (0.2 g) in water (1.5 mL). After stirring for 2 hours the mixture was carefully acidified to pH 5 and then treated with ethyl acetate and sodium chloride. The organic layer was evaporated and the residue was dissolved in dichloromethane. This solution was dried and then evaporated to give the title compound (0.45 g) as a yellow green oil.

後処理

  1. customThe organic layer was evaporated
  2. dissolutionthe residue was dissolved in dichloromethane
  3. customThis solution was dried
  4. customevaporated

出典と根拠

ORDレコード
ord-12a6c9d0dbe642348317d72218628742
出典データセット
uspto-grants-2003_07
特許番号
US06593354B2

反応ノート

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