N-methoxy-N-methyl-4-nitro-2'-methoxymethoxy-6'-methoxy-biphenyl-2-carboxamide → n-Methoxy-n-methyl-4-amino-2'-methoxymethoxy-6'methoxy-biphenyl-2-carboxamide
反応式
[CH3:1][O:2][N:3]([CH3:27])[C:4]([C:6]1[C:7]([C:15]2[C:20]([O:21][CH3:22])=[CH:19][CH:18]=[CH:17][C:16]=2[O:23][CH2:24][O:25][CH3:26])=[CH:8][CH:9]=[C:10]([N+:12]([O-])=O)[CH:11]=1)=[O:5]>CO.[Pd]>[CH3:1][O:2][N:3]([CH3:27])[C:4]([C:6]1[C:7]([C:15]2[C:20]([O:21][CH3:22])=[CH:19][CH:18]=[CH:17][C:16]=2[O:23][CH2:24][O:25][CH3:26])=[CH:8][CH:9]=[C:10]([NH2:12])[CH:11]=1)=[O:5]参加物
4
実験手順
A solution of Example 5B (5.67 g.) was dissolved in methanol (120 mL) and hydrogenated at 4 atm with 10% Pd/C (0.60 g) for 1 hour. The catalyst was removed by filtration and the solution concentrated to give the titled compound (5.44 g).