Water → 4-Azidobenzaldehyde

HRID 1358152

反応式

HRID 1358152 の反応式
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[N-:10]=[N+:11]=[N-:12].[Na+].O>CS(C)=O>[N:10]([C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1)=[N+:11]=[N-:12]

参加物

5

反応物 3

HCID 962WaterHCID 33557Sodium AzideHCID 680234-Fluorobenzaldehyde

生成物 1

HCID 903854-Azidobenzaldehyde

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
105 °C

実験手順

50 g 4-fluoro benzaldehyde and 50 g sodium azide were dispersed in 150 ml dry dimethyl sulfoxide. Subsequently, the mixture was heated for 3 hours at 105° C. while nitrogen was introduced. The mixture was poured into 200 ml water, and the solution extracted with 200 ml dichloro methane (three times). Then the solvent was distilled off by means of a vacuum rotation vaporizer. 53 g of a liquid remained having infrared (IR) and nuclear magnetic resonance (NMR) spectra consistent with the 4-azido benzaldehyde structure.

後処理

  1. additionwas introduced
  2. extractionthe solution extracted with 200 ml dichloro methane (three times)
  3. distillationThen the solvent was distilled off by means of a vacuum rotation vaporizer

出典と根拠

ORDレコード
ord-83d9711f65f642a6b84fcbd04a7e823b
出典データセット
uspto-grants-2003_07
特許番号
US06596460B2

関連ノート

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