252978-96-4 → 2-(5-Fluorobenzofuran-3-yl)ethanol

HRID 1358241ノート

反応式

HRID 1358241 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[C:7]([CH2:10][C:11](O)=[O:12])[C:6]=2[CH:14]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[C:7]([CH2:10][CH2:11][OH:12])[C:6]=2[CH:14]=1

参加物

4

反応物 2

HCID 9158981252978-96-4HCID 21226445Aluminium lithium hydride

生成物 1

HCID 181842942-(5-Fluorobenzofuran-3-yl)ethanol収率 100.7%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 5-fluorobenzofuran-3-ylacetic acid (4.6 g, prepared as described in Example 2) in dry tetrahydrofuran (200 mL) was added dropwise to a suspension of lithium aluminium hydride (4.5 g) in dry tetrahydrofuran (150 mL) at room temperature. After reflux for 2 h the reaction was quenched by successive additions of water (9.2 mL), 15% aq. sodium hydroxide (4.6 mL), water (23 mL). Filtration and removal of solvent in vacuo gave an oil, 2-(5-fluorobenzofuran-3-yl)ethanol (4.3 g).

後処理

  1. temperatureAfter reflux for 2 h the reaction
  2. customwas quenched by successive additions of water (9.2 mL), 15% aq. sodium hydroxide (4.6 mL), water (23 mL)
  3. filtrationFiltration and removal of solvent in vacuo

出典と根拠

ORDレコード
ord-efdeb311179b47cfb10f9c47503c48f6
出典データセット
uspto-grants-2003_07
特許番号
US06596722B2

反応ノート

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