HCID 18184366、化合物 → HCID 18184387、化合物

HRID 1358263ノート

反応式

HRID 1358263 の反応式
[N+:1]([C:4]1[CH:12]=[C:11]([N+:13]([O-])=O)[C:10]([OH:16])=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7])([O-])=O>CO.CCOC(C)=O.[Pd]>[NH2:1][C:4]1[CH:12]=[C:11]([NH2:13])[C:10]([OH:16])=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7]

参加物

4

反応物 1

HCID 18184366HCID 18184366、化合物

生成物 1

HCID 18184387HCID 18184387、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21584119Ethylacetate methanol溶媒

実験手順

A solution of 2,4-dinitro-5-hydroxybenzamide (4.00 g, 0.018 mmol) in MeOH/EtOAc (1:1, 50 mL) is hydrogenated over 5% Pd/C at 60 psi for 3 h to give 2,4-diamino-5-hydroxybenzamide, which is used directly. Formic acid (50 mL) is added and the solution is heated under reflux for 48 h. then the volatiles are removed under reduced pressure. The residue is triturated with EtOAc to give crude 4-oxo-3H-oxazolo[5,4-g]quinazoline (3.27 g, 97%) as a tan powder which is used directly.

出典と根拠

ORDレコード
ord-ac7dcea98dc74a988041834a5570fde8
出典データセット
uspto-grants-2003_07
特許番号
US06596726B1

反応ノート

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