Water → 4-Hydrazinobenzenesulfonic acid morpholide

HRID 1358376ノート

反応式

HRID 1358376 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.O.[NH2:18][NH2:19].O>CN1CCCC1=O>[NH:18]([C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1)[NH2:19]

参加物

5

反応物 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 7553774-((4-Fluorophenyl)sulfonyl)morpholine

生成物 1

HCID 112998664-Hydrazinobenzenesulfonic acid morpholide

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
100 °C

実験手順

5 g of 4-fluorobenzenesulfonic acid morpholide were dissolved in 15 ml of N-methylpyrrolidone and mixed with 2.5 g of hydrazine hydrate, and the mixture was heated at 100° C. for 1 hour. After cooling to room temperature, 75 ml of water were added and the mixture was stirred at room temperature. After 2 hours, the solid was filtered off with suction and recrystallized from isopropanol.

後処理

  1. temperatureAfter cooling to room temperature
  2. filtrationthe solid was filtered off with suction
  3. customrecrystallized from isopropanol

出典と根拠

ORDレコード
ord-32059fe74de94fbab9455921df158db1
出典データセット
uspto-grants-2003_07
特許番号
US06596742B1

反応ノート

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