Oxalic Acid → 3-Nitro-phenethylamine oxalate
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]#[N:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[C:13]([OH:18])(=[O:17])[C:14]([OH:16])=[O:15]>C1COCC1>[C:13]([OH:18])(=[O:17])[C:14]([OH:16])=[O:15].[N+:1]([C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][CH:9]=1)[CH2:10][CH2:11][NH2:12])([O-:3])=[O:2]参加物
4
実験手順
3-Nitrophenyl acetonitrile (6.486 g, 0.04 mol) was refluxed with borane-THF complex (40 mL, 0.04 mole) in anhydrous THF (80 mL) for 45 min under argon. The reaction mixture was quenched with methanol and concentrated. 3-Nitrophenylethyl amine was crystallized from the reaction mixture by adding oxalic acid (10 g, 0.08 mol). Yield 4.36 g, 85%.
後処理
- customThe reaction mixture was quenched with methanol
- concentrationconcentrated
- custom3-Nitrophenylethyl amine was crystallized from the reaction mixture
出典と根拠
- ORDレコード
- ord-bd137f1d77d04b8889d7f0779a4293bb
- 出典データセット
- uspto-grants-2003_07
- 特許番号
- US06596734B1
反応ノート
読み込み中…