Water → 4-Chloro-5-methyl-1H-indole-2,3-dione

HRID 1358477ノート

反応式

HRID 1358477 の反応式
[Cl:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4](SC)[C:5](=[O:12])[NH:6]2.ClN1C(=[O:21])CCC1=O.C1COCC1.O>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4](=[O:21])[C:5](=[O:12])[NH:6]2

参加物

6

反応物 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 31398ChlorosuccinimideHCID 219059304-Chloro-5-methyl-3-(methylthio)indolin-2-one

生成物 1

HCID 225608594-Chloro-5-methyl-1H-indole-2,3-dione収率 80.9%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

This compound is prepared according to the procedure described in stage B of Preparation 1.10 from 0.72 g of 4-chloro-5-methyl-3-methylthio-1,3-dihydro-2H-indol-2-one and 0.422 g of N-chlorosuccinimide in 72 ml of carbon tetrachloride and then from 58 ml of THF and 14 ml of water. The product obtained is chromatographed on silica gel, elution being carried out with DCM and then with the gradient of the DCM/AcOEt mixture up to (90/10, v/v). 0.5 g of the expected product is obtained.

後処理

  1. customThis compound is prepared
  2. customThe product obtained
  3. customis chromatographed on silica gel, elution

出典と根拠

ORDレコード
ord-089851175b4f43688e6648d1ecc71ad6
出典データセット
uspto-grants-2003_07
特許番号
US06596732B2

反応ノート

読み込み中…