Methanol → 2-Methoxy-α-phenyl-4-pyridinemethanol
反応式
[BH4-].[Na+].[C:3]([C:11]1[CH:16]=[CH:15][N:14]=[C:13]([O:17][CH3:18])[CH:12]=1)(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.CO>O>[OH:10][CH:3]([C:11]1[CH:16]=[CH:15][N:14]=[C:13]([O:17][CH3:18])[CH:12]=1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1参加物
5
実験手順
9.4 g of sodium borohydride was added little by little to a mixture of 130 g of 4-benzoyl-2-methoxypyridine and 300 ml of methanol under stirring in an ice bath. After the dropwise addition was completed, the mixture was stirred at room temperature overnight. The reaction solution was added to 1 L of water and then extracted with ethyl acetate. The organic phase was washed with brine, dried over anhydrous magnesium sulfate and then the solvent was removed, to give 104 g of the target compound.
後処理
- additionAfter the dropwise addition
- stirringthe mixture was stirred at room temperature overnight
- extractionextracted with ethyl acetate
- washThe organic phase was washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- customthe solvent was removed
出典と根拠
- ORDレコード
- ord-9df3edc6687f4525bd6eb57cc33161b4
- 出典データセット
- uspto-grants-2003_07
- 特許番号
- US06599917B1
反応ノート
読み込み中…