Hydrochloric Acid → 5-(2-Methyl-1,3-thiazol-4-yl)thiophene-2-carboxylic acid
反応式
[Li+].[OH-].[CH3:3][C:4]1[S:5][CH:6]=[C:7]([C:9]2[S:13][C:12]([C:14]([O:16]C)=[O:15])=[CH:11][CH:10]=2)[N:8]=1.Cl>O1CCOCC1>[CH3:3][C:4]1[S:5][CH:6]=[C:7]([C:9]2[S:13][C:12]([C:14]([OH:16])=[O:15])=[CH:11][CH:10]=2)[N:8]=1参加物
5
実験手順
Aqueous LiOH (1N, 1.5 mL) is added to a solution of methyl 5-(2-methylthiazol-4-yl)-thiophene-2-carboxylate (81 mg, 0.34 mmol) in dioxane (1 mL). The reaction is stirred at room temperature for 2 hours. Aqueous HCl (1N, 4 mL) is added and the resultant precipitate is collected by filtration, washed with water, and dried to give the desired product (53 mg, 69%). 1NMR (300 MHz, DMSO) δ 8.03, 7.69, 7.59, 2.70.
後処理
- filtrationthe resultant precipitate is collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-1f0e2b26693a4f8d92d0fd8f8354769f
- 出典データセット
- uspto-grants-2003_07
- 特許番号
- US06599916B2
反応ノート
読み込み中…