Ethyl Acetate → tert-Butyl 4-amino-2-chlorobenzoate

HRID 1360318ノート

反応式

HRID 1360318 の反応式
[Cl:1][C:2]1[CH:14]=[C:13]([N+:15]([O-])=O)[CH:12]=[CH:11][C:3]=1[C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5].C(OCC)(=O)C>C(O)C.[Pt]>[NH2:15][C:13]1[CH:12]=[CH:11][C:3]([C:4]([O:6][C:7]([CH3:9])([CH3:10])[CH3:8])=[O:5])=[C:2]([Cl:1])[CH:14]=1

参加物

5

反応物 2

HCID 8857Ethyl AcetateHCID 22593093tert-Butyl 2-chloro-4-nitrobenzoate

生成物 1

HCID 53432585tert-Butyl 4-amino-2-chlorobenzoate収率 96.3%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 702Ethanol溶媒

実験手順

To a solution of tert-butyl 2-chloro-4-nitro-benzoate (2.05 g, 7.98 mmol) in ethanol 12 mL) and ethyl acetate (108 mL) was added platinum on activated charcoal (5%, 295 mg), and the mixture was stirred under at room temperature under a hydrogen atmosphere (1 bar). After filtration through a pad of diatomaceous earth, the filtrate was evaporated to afford tert-butyl 4-amino-2-chlorobenzoate (1.75 g, 96%). Orange solid, MS (EI)=227.2 (M+).

後処理

  1. filtrationAfter filtration through a pad of diatomaceous earth
  2. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-1479539115ae46ec953a5bb72958e206
出典データセット
uspto-grants-2011_02
特許番号
US07879845B2

反応ノート

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