Hydrochloric Acid → 6-(Aminomethyl)picolinic acid hydrochloride
反応式
[C:1]([C:3]1[N:8]=[C:7]([C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=1)#[N:2].[ClH:12].[H][H]>C(O)C.[Pd]>[ClH:12].[NH2:2][CH2:1][C:3]1[N:8]=[C:7]([C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=1参加物
6
実験手順
6-Cyano-pyridine-2-carboxylic acid (compound F2) (250 mg, 1.6 mmol) is dissolved in ethanol (100 mL), concentrated hydrochloric acid (1 mL) and Pd/C (150 mg) are added and the mixture is hydrogenated at 3 bar hydrogen pressure for 6 h. The catalyst is filtered of and the crude product is transferred to the next step without any purification.
後処理
- filtrationThe catalyst is filtered of and the crude product
- customis transferred to the next step without any purification
出典と根拠
- ORDレコード
- ord-14864f76feee44109c49919adfc17e23
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07879853B2
反応ノート
読み込み中…