Hydrochloric Acid → 2-(2,6-Dichloro-phenyl)-3H-benzoimidazole-5-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[CH:21]=[CH:20][C:8]2[N:9]=[C:10]([C:12]3[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:19])[NH:11][C:7]=2[CH:6]=1)=[O:4].[OH-].[Na+].Cl>CO.C1COCC1>[Cl:19][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]([Cl:18])[C:12]=1[C:10]1[NH:11][C:7]2[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:21]=[CH:20][C:8]=2[N:9]=1参加物
5
実験手順
To a solution of 2-(2,6-dichlorophenyl)-3H-benzoimidazole-5-carboxylic acid methyl ester (5.8 g) in 40 mL of MeOH/THF (1:1) was added 1N NaOH (20 mL). The mixture was stirred at RT for 18 h then 1N HCl was added until pH 3. The resulting precipitate was filtered, washed with water and dried under reduced pressure to give the title compound.
後処理
- filtrationThe resulting precipitate was filtered
- washwashed with water
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-187f64f8474244f4b37d6cf2004e6838
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07879850B2
反応ノート
読み込み中…