[5-(4-Amino-3-nitrophenyl)-[1,3,4]oxadiazol-2-yl]-(3-chlorophenyl)-amine → 4-[5-(3-Chlorophenylamino)-[1,3,4]oxadiazol-2-yl]-benzene-1,2-diamine

HRID 1360776ノート

反応式

HRID 1360776 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=3)=[N:10][N:9]=2)=[CH:4][C:3]=1[N+:21]([O-])=O>CO.O=[Pt]=O>[Cl:20][C:16]1[CH:15]=[C:14]([NH:13][C:11]2[O:12][C:8]([C:5]3[CH:4]=[C:3]([NH2:21])[C:2]([NH2:1])=[CH:7][CH:6]=3)=[N:9][N:10]=2)[CH:19]=[CH:18][CH:17]=1

参加物

4

反応物 1

HCID 66966422[5-(4-Amino-3-nitrophenyl)-[1,3,4]oxadiazol-2-yl]-(3-chlorophenyl)-amine

生成物 1

HCID 669663754-[5-(3-Chlorophenylamino)-[1,3,4]oxadiazol-2-yl]-benzene-1,2-diamine

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

A suspension of [5-(4-amino-3-nitrophenyl)-[1,3,4]oxadiazol-2-yl]-(3-chlorophenyl)-amine (245 mg, 0.74 mmol) and PtO2 (50 mg) in MeOH (30 mL) was hydrogenated at one atm for 4 h. The catalyst was filtered over Celite and the filtrate was evaporated under reduced pressure to give the title compound. This was used directly in the next reaction.

後処理

  1. filtrationThe catalyst was filtered over Celite
  2. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-289a245b27b948e2890f223a63444d17
出典データセット
uspto-grants-2011_02
特許番号
US07879850B2

反応ノート

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