Water → 6H-thiazolo[5,4-e]indazol-2-amine

HRID 1360834

反応式

HRID 1360834 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.[S-:11][C:12]#[N:13].[Na+].BrBr.O>C(O)(=O)C>[S:11]1[C:3]2[C:4]3[CH:5]=[N:6][NH:7][C:8]=3[CH:9]=[CH:10][C:2]=2[N:1]=[C:12]1[NH2:13]

参加物

6

反応物 4

HCID 962WaterHCID 24408BromineHCID 880121H-Indazol-5-amineHCID 516871Sodium thiocyanate

生成物 1

HCID 450776746H-thiazolo[5,4-e]indazol-2-amine収率 108.6%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

2.0 g (15 mmol) of 5-aminoindazole and 4.9 g (60.5 mmol) of sodium thiocyanate were suspended in 10 ml of acetic acid, and 2.4 g (15 mmol) of bromine was added dropwise to the suspension under ice-cooling. The reaction mixture was allowed to warm to room temperature, and it was stirred overnight. The reaction mixture was poured into water, and the resulting crystals were collected by filtration to give 3.1 g of 6H-pyrazolo[4′,3′:3,4]benzo[1,2-d]thiazol-2-ylamine.

後処理

  1. temperaturecooling
  2. filtrationthe resulting crystals were collected by filtration

出典と根拠

ORDレコード
ord-a08db6a131d245279357b2eff5f3a1bc
出典データセット
uspto-grants-2011_02
特許番号
US07879887B2

関連ノート

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