Sulfuric Acid → 4-nitro-6H-pyrazolo[4',3':3,4]benzo[1,2-d]thiazol-2-ylamine

HRID 1360835

反応式

HRID 1360835 の反応式
[N+:1]([O-:4])([O-])=[O:2].[Na+].[S:6]1[C:10]2[C:11]3[CH:17]=[N:16][NH:15][C:12]=3[CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[NH2:18].S(=O)(=O)(O)O>>[N+:1]([C:14]1[C:9]2[N:8]=[C:7]([NH2:18])[S:6][C:10]=2[C:11]2[CH:17]=[N:16][NH:15][C:12]=2[CH:13]=1)([O-:4])=[O:2]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 24268Sodium NitrateHCID 450776746H-thiazolo[5,4-e]indazol-2-amine

生成物 1

HCID 579512644-nitro-6H-pyrazolo[4',3':3,4]benzo[1,2-d]thiazol-2-ylamine収率 68%

実験手順

Under ice-cooling, 184 mg (2.17 mmol) of sodium nitrate was added to a mixture of 191 mg (1.01 mmol) of 6H-pyrazolo[4′,3′:3,4]benzo[1,2-d]thiazol-2-ylamine and 3 ml of concentrated sulfuric acid, and the mixture was stirred for 0.5 hours. The reaction mixture was poured onto ice, and the precipitated solid was collected by filtration, and then washed with water and methanol to give 160 mg (yield: 68%) of 4-nitro-6H-pyrazolo[4′,3′:3,4]benzo[1,2-d]thiazol-2-ylamine.

後処理

  1. temperatureUnder ice-cooling
  2. additionThe reaction mixture was poured onto ice
  3. filtrationthe precipitated solid was collected by filtration
  4. washwashed with water and methanol

出典と根拠

ORDレコード
ord-0bed401fe72d48eebf2cae23634b86ec
出典データセット
uspto-grants-2011_02
特許番号
US07879887B2

関連ノート

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