Benzoyl chloride → 3-Benzoylamino-4-methyl-benzotrifluoride

HRID 1360836

反応式

HRID 1360836 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:10][C:11]1[CH:12]=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:14]=[CH:15][C:16]=1[CH3:17]>N1C=CC=CC=1>[C:1]([NH:10][C:11]1[CH:12]=[C:13]([C:18]([F:19])([F:20])[F:21])[CH:14]=[CH:15][C:16]=1[CH3:17])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 7412Benzoyl chlorideHCID 27359332-Methyl-5-(trifluoromethyl)aniline

生成物 1

HCID 579513963-Benzoylamino-4-methyl-benzotrifluoride収率 100%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Under ice-cooling, 4.0 ml (34.5 mmol) of benzoyl chloride was added dropwise to a mixture of 4.97 g (28.8 mmol) of 3-amino-4-methyl-benzotrifluoride and 10 ml of pyridine. After stirring the mixture at room temperature for 1 hour, the solvent was removed under reduced pressure, and water was added to the residue. The precipitated solid was collected by filtration and then washed with water and a 50% aqueous methanol solution to give 8.04 g of 3-benzoylamino-4-methyl-benzotrifluoride.

後処理

  1. temperatureUnder ice-cooling
  2. customthe solvent was removed under reduced pressure, and water
  3. additionwas added to the residue
  4. filtrationThe precipitated solid was collected by filtration
  5. washwashed with water

出典と根拠

ORDレコード
ord-2171ad41a7da4a56b150ef7b2cbb3795
出典データセット
uspto-grants-2011_02
特許番号
US07879887B2

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